FEATURES OF THE FUNCTIONAL STATE OF KIDNEYS IN PATIENTS WITH CHRONIC HEART FAILURE 

Grishina Natal'ya Pavlovna, Senior laboratory assistant, sub-department of hospital therapy named after R. G. Mezhebovskiy, Orenburg State Medical University (6/45/7 Sovetskaya street/M. Gorkogo street/Dmitrievskiy lane, Orenburg, Russia), E-mail: ngrishina1@yandex.ru
Lopina Ekaterina Anatol'evna, Assistant, sub-department of hospital therapy named after R. G. Mezhebovskiy, Orenburg State Medical University (6/45/7 Sovetskaya street/M. Gorkogo street/Dmitrievskiy lane, Orenburg, Russia), E-mail: ekaterina_lopina@mail.ru
Libis Roman Aronovich, Doctor of medical sciences, professor, head of sub-department of hospital therapy named after R. G. Mezhebovskiy, Orenburg State Medical University (6/45/7 Sovetskaya street/M. Gorkogo street/Dmitrievskiy lane, Orenburg, Russia), E-mail: rlibis@gmail.com 

616.12-008.46-039-036.12-02:612.46 

10.21685/2072-3032-2019-2-1 

Background. Diseases of the cardiovascular system occupy a leading place in the structure of hospitalization and mortality, the leading position belongs to the developmentof chronic heart failure. The development of renal failure and the manifestation of symptoms of the cardiorenal continuum lead to a significant deterioration in the prognosis of this group of patients. Objective: to study the functional features of the kidney in patients with chronic heart failure in the gender aspect.
Materials and methods. Fifty patients suffering from chronic heart failure, aged 60 to 70 years, were examined. All patients underwent ECO-CS to assess the state of the myocardium and analysis of serum and urine to determine kidney function.
Results. The study confirmed the close relationship of cardiovascular disease and their mutual influence with negative dynamics.
Conclusion. In the group of women revealed more significant changes in structural and functional indicators of the myocardium, indicating the progression of diastolic CHF. In addition, there is a more significant decrease in the functional ability of the kidneys compared with a group of men; Both men and women showed CKD progression as CHF worsened; The resulting relationship between LVEF and GFR in combination with the albumin-creatinine ratio may indicate the formation of the cardiorenal continuum in this cohort of patients. 

chronic heart failure, chronic kidney disease, cardiorenal continuum 

1. Richards M. Journal of the American College of Cardiology. 2012, no. 60, pp. 969–970.
2. Metra M., Cotter G., Davison B. A., Felker G. M., Filippatos G., Greenberg B. H., Ponikowski P., Unemori E., Voors A. A., K. F. Adams Jr., Dorobantu M. I., Grinfeld L., Jondeau G., Marmor A., Masip J., Pang P. S., Werdan K., Prescott M. F., Edwards C., Teichman S. L., Trapani A., Bush C. A., Saini R., Schumacher C., Severin T., Teerlink J. R. Journal of the American College of Cardiology. 2013, no. 61, pp. 196–206.
3. Smirnov A. V., Shilov E. M., Dobronravov V. A., Kayukov I. G., Bobkova I. N., Shvetsov M. Yu., Tsygin A. N., Shutov A. M. Klinicheskaya nefrologiya [Clinical nephrology]. 2012, no. 4, pp. 4–26. [In Russian]
4. Bleuming G. S., Knetsch A. M., Sturkenboom M. C., Straus S. M., Hofman A., Deckers J. W., Witteman J. C., Stricker B. H. European Heart Journal. 2004, no. 25 (18), pp. 1614–1619.
5. Fomin I. V., Belenkov Yu. N., Mareev V. Yu., Ageev F. T., Badin Yu. V., Galyavich A. S., Danielyan M. O., Kamalov G. M., Kechedzhieva S. G., Makarova V. G., Makarova N. V., Malenkova V. Yu., Sayfutdinov R. I., Tarlovskaya E. I., Khokhlov R. A., Shcherbinina E. V., Yakushin S. S. Serdechnaya nedostatochnost' [Heart failure]. 2006, vol. 1, no. 35, pp. 4–7. [In Russian]
6. Campbell R. C., Sui S., Filippatos G. et al. Nephrol. Dial. Transplant. 2009, no. 24, pp. 186–193.
7. Tereshchenko S. N., Zhirov I. V. Serdechnaya nedostatochnost' [Heart failure]. 2008, no. 6, pp. 295–298. [In Russian]
8. Shiba N., Matsuki M., Takahashi J., Tada T., Watanabe J., Shimokawa H. Circulation Journal. 2008, no. 72 (2), pp. 173–178.
9. Klinicheskie rekomendatsii OSSN – RKO – RNMOT. Serdechnaya nedostatochnost': khronicheskaya (KhSN) i ostraya dekompensirovannaya (ODSN). Diagnostika, profilaktika i lechenie [Clinical guidelines SSHF – RCS – RSMST. Heart failure: chronic (CHF) and acute decompensated (ADHF)]. Moscow, 2018. [In Russian]
10. Natsional'nye rekomendatsii po diagnostike i lecheniyu stabil'noy stenokardii [National guidelisen on diagnosing and treatment of stable angine]. Moscow, 2008. [In Russian]
11. Chazova I. E., Ratova L. G., Boytsov S. A., Nebieridze D. V. Sistemnye gipertenzii [Systemic hypertensions]. 2010, no. 3, pp. 5–26. [In Russian]
12. Natsional'nye rekomendatsii: Serdechno-sosudistyy risk i khronicheskaya bolezn' pochek: strategii kardio-nefroprotektsii [National guidelines: cardiovascular risk and chronic renal disease: strategies of cardio-nephroprotection]. Moscow, 2014. [In Russian]
13. Rebrova O. Yu. Statisticheskiy analiz meditsinskikh dannykh [Statistical analysis of medical data]. Moscow: Media Sfera, 2006, 305 p. [In Russian] 
14. Berl T., Henrich W. Clinical Journal of the American Society of Nephrology. 2006, no. 1, pp. 8–18.
15. Bock J. S., Gottlieb S. S. Circulation. 2010, no. 121 (23), pp. 2592–2600.
16. Serov V. A. Kardiorenal'nye vzaimootnosheniya u bol'nykh s khronicheskoy serdechnoy nedostatochnost'yu: avtoref. dis. d-ra med. nauk [Cardiorenal interrelations in patients with chronic heart failure: author’s abstract of dissertation to apply for the degree of the doctor of medical sciences]. Ulyanovsk, 2011. [In Russian]
17. Dagres N., Kremastinos D. Th., Nieuwlaat R., Crijns H. J., Vardas P. E., Andresen D., Lévy S., Cobbe S., Breithardt G., Cokkinos D. V. Journal of the American College of Cardiology. 2007, no. 49 (5), pp. 572–577.